References

1. K. Fent, A.A. Weston, D. Caminada, Ecotoxicology of human pharmaceuticals, Aquat. Toxicol., 76 (2006) 122–159.
2. G.A. Mills, B. Vrana, I. Allan, D.A. Alvarez, J.N. Huckins, R. Greenwood, Trends in monitoring pharmaceuticals and personal-care products in the aquatic environment by use of passive sampling devices, Anal. Bioanal. Chem., 387 (2007) 1153–1157.
3. J.D.G. Larsson, C. de Pedro, N. Paxeus, Effluent from drug manufactures contains extremely high levels of pharmaceuticals, J. Hazard. Mater., 148 (2007) 751–755.
4. K. Kümmerer, Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks. Springer-Verlag, Berlin Heidelberg, 2008, pp. 223–244.
5. M. Łebkowska, M. Załęska-Radziwiłł, K. Affek, Substancje farmaceutyczne w środowisku wodnym – występowanie i zagrożenia [Pharmaceuticals in aquatic environment – occurrence and effects], Gaz, Woda Techn. Sanit., 3 (2012) 129–133.
6. M.S. Kostich, A.L. Batt, J.M. Lazorchak, Concentrations of prioritized pharmaceuticals in effluents from 50 large wastewater treatment plants in the US and implications for risk estimation, Environ. Pollut., 184 (2014) 354–359.
7. R. Andreozzi, M. Raffaele, P. Nicklas, Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment, Chemosphere, 50 (2003) 1319–1330.
8. N. Doerr-MacEwen, M.E. Haight, Expert stakeholders’ views on the management of human pharmaceuticals in the environment, Environ. Manage., 38 (2006) 853–866.
9. A.B. Boxall, M.A. Rudd, B.W. Brooks, D.J. Caldwell, K. Choi, S. Hickmann, E. Innes, K. Ostapyk, J.P. Staveley, T. Verslycke, G.T. Ankley, K.F. Beazley, S.E. Belanger, J.P. Berninger, P. Carriquiriborde, A. Coors, P.C. Deleo, S.D. Dyer, J.F. Ericson, F. Gagné, J.P. Giesy, T. Gouin, L. Hallstrom, M.V. Karlsson, D.G. Larsson, J.M. Lazorchak, F. Mastrocco, A. McLaughlin, M.E. McMaster, R.D. Meyerhoff, R. Moore, J.L. Parrott, J.R. Snape, R. Murray-Smith, M.R. Servos, P.K. Sibley, J.O. Straub, N.D. Szabo, E. Topp, G.R. Tetreault, V.L. Trudeau, G. Van Der Kraak, Pharmaceuticals and personal care products in the environment: what are the big questions?, Environ. Health Perspect., 120 (2012) 1221–1229.
10. SCHER, SCCS, SCENIHR, Opinion on the Toxicity and Assessment of Chemical Mixtures, 2012.
11. T. Backhaus, R. Alterburger, W. Boedeker, M. Faust, M. Scholze, L.H. Grimme, Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri, Environ. Toxicol. Chem., 19 (2000) 2348–2356.
12. T. Backhaus, M. Scholze, L.H. Grimme, The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri, Aquat. Toxicol., 49 (2000) 49–61.
13. S. Brosché, Effects of Pharmaceuticals on Natural Microbial Communities. Tolerance Development, Mixture Toxicity and Synergistic Interactions, Faculty of Science, Department of Plant and Environmental Sciences, Faculty of Science, University of Gothenburg, 2010.
14. A.R. Boobis, R. Budisky, S. Collie, K. Crofton, M. Embry, S. Felter, R. Hetzberg, D. Kopp, G. Mihlan, M. Mumtaz, P. Price, K. Solomon, L. Teuschler, R. Yang, R. Zaleski, Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment, Crit. Rev. Toxicol., 41 (2011) 369–383.
15. S.D. Melvin, M.C. Cameron, C.M. Lanctôt, Individual and mixture toxicity of pharmaceuticals naproxen, carbamazepine, and sulfamethoxazole to Australian striped marsh frog tadpoles (Limnodynastes peronii), J. Toxicol. Environ. Health A, 77 (2014) 337–345.
16. T.C. Chou, Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies, Pharmacol. Rev., 58 (2006) 621–681.
17. P. Shakya, Synergism and Antagonism in Toxicity of Mixtures of Pharmaceuticals to Daphnia magna, Senior Theses, Trinity College, Hartford, CT, 2011.
18. L.-H. Yang, G.-G. Ying, H.-C. Su, J.L. Stauber, M.S. Adams, M.T. Binet, Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata, Environ. Toxicol. Chem., 27 (2008) 1201–1208.
19. M. Cleuvers, Mixture toxicity of the anti-inflammatory drugs diclofenac. Ibuprofen, naproxen and acetylsalicylic acid, Ecotoxicol. Environ. Saf., 59 (2004) 309–315.
20. F. Pomati, C. Orlandi, M. Clerici, F. Luciani, E. Zuccato, Effects of interactions in an environmentally relevant mixture of pharmaceuticals, Toxicol. Sci., 102 (2008) 129–137.
21. M. Załęska-Radziwiłł, K. Affek, N. Doskocz, Ecotoxicological risk assessment of chosen pharmaceuticals detected in surface waters, J. Environ. Sci. Health A, 52 (2017) 1233–1239.
22. M. Załęska-Radziwiłł, K. Affek, J. Rybak, Ecotoxicity of chosen pharmaceuticals in relation to microorganisms – risk assessment, Desal. Wat. Treat., 52 (2014) 3908–3917.
23. M. Załęska-Radziwiłł, M. Łebkowska, K. Affek, A. Zarzeczna, Environmental risk assessment of selected pharmaceuticals present in surface waters in relation to animals, Arch. Environ. Prot., 37 (2011) 31–42.
24. M. Załęska-Radziwiłł, M. Łebkowska, K. Affek, N. Chrzanowska, Ecotoxicological risk assessment of selected pharmaceuticals in relation to cyanobacteria and plants (in Polish), Ochr. Śr. Zasobów Nat., 48 (2011) 372–382.
25. K. Kümmerer, A. Al-Ahmad, V. Mersch-Sundermann, Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test, Chemosphere, 40 (2000) 701–710.
26. B. Halling-Sǿrensen, H.C. Holten Lützhǿft, H.R. Andersen, F. Ingerslev, Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin, J. Antimicrob. Chemother., 46 (2000) 53–58.
27. H. Sanderson, D.J. Johnson, C.J. Wilson, R.A. Brain, K.R. Solomon, Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and alga by ECOSAR screening, Toxicol. Lett., 144 (2003) 383–395.
28. J.O. Straub, Combined environmental risk assessment for 5-fluorouracil and capecitabine in Europe, Integr. Environ. Assess. Manage., 6 (2009) 540–566.
29. M. Artoxkit, Estuarine and Marine Waters Toxicity Screening Test, Standard Operational Procedure, Microbiotests Inc., Belgium.
30. OECD Guidelines for the Testing of Chemicals. Test No. 202: Daphnia sp. acute immobilisation test, OECD, Paris, 2004.
31. E.Q. Espiritu, C.R. Jansen, G. Persoone, Cyst-based toxicity tests VII. Evaluation of the 1 hour enzymatic inhibition test (Fluotox) with Artemia nauplii, Environ. Toxicol. Water Qual., 10 (1995) 25–34.
32. OECD Guidelines for the Testing of Chemicals. Test No. 21: Daphnia magna reproduction test, OECD, Paris, 1998.
33. PN-EN ISO 8692:2012, Water Quality – Growth Inhibition of Freshwater Algae Using Unicellular Green Algae.
34. PN-EN ISO 20079:2006, Water Quality – Determination of the Toxic Effect of Water Constituents and Waste Water to Duckweed (Lemna minor) – Duckweed Growth Inhibition Test.
35. C.I. Bliss, The toxicity of poisons applied jointly, Annu. J. Appl. Biol., 26 (1939) 585–615.
36. M. González-Pleiter, G. Soledad, I. Rodea-Palomares, F. Leganés, R. Rosal, K. Boltes, E. Marco, F. Fernández-Piñas, Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment, Water Res., 47 (2013) 2050–2064.
37. C.M. Flaherty, S.I. Dodson, Effects of pharmaceuticals on Daphnia survival, growth and reproduction, Chemosphere, 61 (2005) 200–207.
38. A. Krotenkamp, T. Backhaus, M. Faust, State of the Art Report on Mixture Toxicity, Final Report to the European Commission, Contract no 070307/2007/485103/ETU/D.12009.
39. M. Faust, R. Alterburger, T. Backhaus, H. Blank, W. Bodeker, P. Gramatica, V. Hamer, M. Scholze, M. Vighi, L.H. Grimme, Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action, Aquat. Toxicol., 63 (2003) 43–63.
40. N. Cedegreen, A.M. Christensen, A. Kamper, P. Kudsk, S.K. Mathiassen, J.C. Streibig, H. Sørensen, A review of independent action compared to concentration addition as reference models for mixtures of compounds with different molecular target sites, Environ. Toxicol. Chem., 27 (2008) 1621–1632.
41. T. Backhaus, J. Sumpter, H. Blanck, On the Ecotoxicology of Pharmaceutical Mixtures, K. Kümmerer, Ed., Pharmaceuticals in the Environment. Springer, Berlin, Heidelberg, 2008, pp. 257–276.
42. I. Rodea-Palomares, M. González-Pleiter, K. Martín-Betancor, R. Rosal, F. Fernández-Piñas, Additivity and interactions in ecotoxicity of pollutant mixtures: some patterns, conclusions and open questions, Toxics, 3 (2015) 342–369.