References

  1. A. Sokół, K. Borowska, J. Karpińska, Investigating the influence of some environmental factors on the stability of paracetamol, naproxen, and diclofenac in simulated natural conditions, Pol. J. Environ. Stud., 26 (2017) 293–302.
  2. T. Heberer, Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data, Toxicol. Lett., 131 (2002) 5–17.
  3. P. Iovino, S. Chianese, S. Canzano, M. Prisciandaro, D. Musmarra, Degradation of ibuprofen in aqueous solution with UV light: the effect of reactor volume and pH, Water Air Soil Pollut., 227 (2016) 1–9.
  4. K. Kümmerer, Pharmaceuticals in the Environment: Sources, Fate, Effects and Risks, Springer, Berlin, 2001.
  5. L.A. Maranho, M.C. Garrido-Perez, T.A. Delvalls, M.I. Martin- Diaz, Suitability of standardized acute toxicity tests for marine sediment assessment: pharmaceutical contamination, Water Air Soil Pollut., 226 (2015) 1–14.
  6. A. Nikolaou, S. Meric, D. Fatta, Occurrence patterns of pharmaceuticals in water and wastewater environments, Anal. Bioanal. Chem., 387 (2007) 1225–1234.
  7. S. Rodriguez-Mozaz, H. Weinberg, Meeting report: pharmaceuticals in water—an interdisciplinary approach to a public health challenge, Environ. Health Perspect., 118 (2010) 1016–1020.
  8. M.C. Casado-Martinez, M. Wildi, B.J.D. Ferrari, I. Werner, Prioritization of substances for national ambient monitoring of sediment in Switzerland, Environ. Sci. Pollut. Res., 25 (2018) 3127–3138.
  9. K.O. K’Oreje, F.J. Kandie, L. Vergeynst, M.A. Abira, H. van Langenhove, M. Okoth, K. Demeestere, Occurrence, fate, and removal of pharmaceuticals, personal care products and pesticides in wastewater stabilization ponds and receiving rivers in the Nzoia Basin, Kenya, Sci. Total Environ., 637–638 (2018) 336–348.
  10. Y. Chen, Z. Wang, Z. Shen, Z. Ou, D. Xu, Z. Yuan, S. Zhou, Effects of oxytetracycline on growth and chlorophyll fluorescence in rape (Brassica campestris L.), Pol. J. Environ. Stud., 26 (2017) 995–1001.
  11. N. Milić, M. Milanović, J. Radonić, M. Turk Sekulić, A. Mandić, D. Orcić, A. Misan, I. Milovanović, N. Grujić Letić, M. Vojinović Miloradov, The occurrence of selected xenobiotics in the Danube river via LC-MS/MS, Environ. Sci. Pollut. Res., 25 (2018) 11074–11083.
  12. A.B.A. Boxall, M.A. Rudd, B.W. Brooks, D.J. Caldwell, K. Choi, Pharmaceuticals and personal care products in the environment: what are the big questions?, Environ. Health Perspect., 120 (2012) 1221–1229.
  13. L. Santos, A. Araujo, A. Fachini, A. Pena, C. Delerue-Matos, M. Montenegro, Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment, J. Hazard. Mater., 175 (2010) 45–95.
  14. N. Azimi, A.H. Hassani, G.N. Darzi, S.M. Borghei, Biodegradation of wastewater containing a high concentration of sulfamethoxazole by antibiotic adopted biofilm in attached growth bioreactor, Pol. J. Environ. Stud., 26 (2017) 2463–2469.
  15. B. Halling-Sorensen, S.N. Nielsen, P.F. Lanzky, F. Ingerslev, H.C. Holten Lützhoft, S.E. Jorgensen, Occurrence, fate, and effects of pharmaceutical substances in the environment: a review, Chemosphere, 36 (1998) 357–393.
  16. S.E. Jorgensen, B. Halling-Sorensen, Drugs in the environment, Chemosphere, 40 (2000) 691–699.
  17. P. Nowicki, J. Klos, Z.J. Kokot, Trends of amphetamine type stimulants DTR mass load in poznan based on wastewater analysis, Iran. J. Public Health, 43 (2014) 610–620.
  18. R. Pal, M. Megharaj, K. Kirkbride, R. Naidu, Illicit drugs and the environment–a review, Sci. Total Environ., 463–464 (2013) 1079–1092.
  19. Z. Zhou, Y. Wang, H. Yu, Z. Zhang, J. Wang, H. Lv, Estimation of ten illicit drugs abuse in Hangzhou through sewage-based analysis, Acta Pol. Pharm., 75 (2018) 247–254.
  20. F. Desbiolles, L. Malleret, C. Tiliacos, P. Wong-Wah-Chung, I. Laffont-Schwob, Occurrence and ecotoxicological assessment of pharmaceuticals: is there a risk for the Mediterranean aquatic environment?, Sci. Total Environ., 639 (2018) 1334–1348.
  21. V. Cunningham, S. Binks, M. Olson, Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment, Regul. Toxicol. Pharm., 53 (2009) 39–45.
  22. W.C. Li, Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil, Environ. Pollut., 187 (2014) 193–201.
  23. S.T. Glassmeyer, E.T. Furlong, D.W. Kolpin, J.D. Cahill, S.D. Zaugg, S.L. Werner, M.T. Meyer, D.D. Kryak, Transport of chemical and microbial compounds from known wastewater discharges: potential for use as indicators of human fecal contamination, Environ. Sci. Technol., 39 (2005) 5157–5169.
  24. M. Petrovic, M. Gros, D. Barcelo, Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry, J. Chromatogr. A, 1124 (2006) 68–81.
  25. T.A. Ternes, Occurrence of drugs in German sewage treatment plants and rivers, Water Res., 32 (1998) 3245–3260.
  26. K. Kümmerer, The presence of pharmaceuticals in the environment due to human use–present knowledge and future challenges, J. Environ. Manage., 90 (2009) 2354–2366.
  27. E. Godfrey, W.W. Woessner, M.J. Benotti, Pharmaceuticals in on-site sewage effluent and ground water, Western Montana, Ground Water, 45 (2007) 263–271.
  28. E.Z. Harrison, S.R. Oakes, M. Hysell, A. Hay, Organic chemicals in sewage sludges, Sci. Total Environ., 367 (2006) 481–497.
  29. C.A. Kinney, E.T. Furlong, D.W. Kolpin, M.R. Burkhardt, S.D. Zaugg, S.L. Werner, J.P. Bossio, M.J. Benotti, Bioaccumulation of pharmaceuticals and other anthropogenic waste indicators in earthworms from agricultural soil amended with biosolid or swine manure, Environ. Sci. Technol., 42 (2008) 1863–1870.
  30. D.J. Lapworth, N. Baran, M.E. Stuart, R.S. Ward, Emerging organic contaminants in groundwater: a review of sources, fate, and occurrence, Environ. Pollut., 163 (2012) 287–303.
  31. B. Reoyo-Prats, D. Aubert, A. Sellier, B. Roig, C. Palacios, Dynamics and sources of pharmaceutically active compounds in a coastal Mediterranean river during heavy rains, Environ. Sci. Pollut. Res., 25 (2018) 6107–6121.
  32. Y.-C. Lin, K.-W. Hsiao, A.Y.-C. Lin, Photolytic degradation of ciprofloxacin in soild and aqueous environments: kinetics, phototransformation pathways, and byproducts, Environ. Sci. Pollut. Res., 25 (2018) 2303–2312.
  33. J.O. Tijani, O.O. Fatoba, L.F Petrik, A review of pharmaceuticals and endocrine-disrupting compounds: sources, effects, removal and detections, Water Air Soil Pollut., 224 (1770) (2013) 1–29.
  34. S. Hussain, M. Naeem, M.N. Chaudhry, Estimation of residual antibiotics in pharmaceutical effluents and their fate in affected areas, Pol. J. Environ. Stud., 25 (2016) 607–614.
  35. de H.A. Brackers, S. Bony, A. Devaux, J. Guitton, Y. Perrodin, Ecotoxicological risk assessment linked to the discharge by hospitals of bio-accumulative pharmaceuticals into aquatic media: the case of mitotane, Chemosphere, 93 (2013) 2365–2372.
  36. T.-D.-H. Vo, X.-T. Bui, N.-D.-T. Cao, V.-P. Luu, T.-T. Nguyen, B.-T. Dang, M.-Q. Thai, D.-D. Nguyen, T.-S. Nguyen., Q.-T. Dinh, T.-S. Dao, Investigation of antibiotics in health care wastewater in Ho Chi Minh City, Vietnam, Environ. Monit. Assess., 188 (2016) 686.
  37. P. Stackelberg, E. Furlong, M. Meyer, S. Zaugg, A. Henderson, D. Reissman, Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-water-treatment plant, Sci. Total Environ., 329 (2004) 99–113.
  38. Z. Ye, H.S. Weinberg, M. Meyer, Occurrence of Antibiotics in Drinking Water, M. Meyer, H. Weinberg, Z. Ye, Eds., Method Development for the Occurrence of Residual Antibiotics in Drinking Water, Water Resources Research Institute of the University of North Carolina, N.C. Raleigh, 2005.
  39. K. Fent, A.A. Weston, D. Caminada, Ecotoxicology of human pharmaceuticals, Aquat. Toxicol., 76 (2006) 122–159.
  40. E.M. Golet, I. Xifra, H. Siegrist, A.C. Alder, W. Giger, Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil, Environ. Sci. Technol., 37 (2003) 3243–3249.
  41. H.A. Duong, N.H. Pham, H.T. Nguyen, T.T. Hoang, H.V. Pham, V.C. Pham, M. Berg, W. Giger, A.C. Alder, Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam, Chemosphere, 72 (2008) 968–973.
  42. R. Hirsch, T. Ternes, K. Haberer, K.-L. Kratz, Occurrence of antibiotics in the aquatic environment, Sci. Total Environ., 225 (1999) 109–118.
  43. A. Watkinson, E. Murby, D. Kolpin, S. Costanzo, The occurrence of antibiotics in an urban watershed: from wastewater to drinking water, Sci. Total Environ., 407 (2009) 2711–2723.
  44. K. Karthikeyan, M. Meyer, Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA, Sci. Total Environ., 361 (2006) 196–207.
  45. M.J. López de Alda, D. Barceló, Determination of steroid sex hormones and related synthetic compounds considered as endocrine disrupters in water by liquid chromatography–diode array detection–mass spectrometry, J. Chromatogr. A, 892 (2000) 391–406.
  46. G.-G. Ying, R.S. Kookana, Y.-J. Ru, Occurrence, and fate of hormone steroids in the environment, Environ. Int., 28 (2002) 545–551.
  47. C.P. Silva, M. Otero, V. Esteves, Processes for the elimination of estrogenic steroid hormones from water: a review, Environ. Pollut., 165 (2012) 38–58.
  48. E. Diaz-Torres, R. Gibson, F. Gonzalez-Farias, A.E. Zarco-Arista, M. Mazarai-Hiriart, Endocrine disruptors in the Xochimilco Wetland, Mexico City, Water Air Soil Pollut., 224 (2013) 1–11.
  49. W. Baran, E. Adamek, J. Ziemiańska, A. Sobczak, Effects of the presence of sulfonamides in the environment and their influence on human health, J. Hazard. Mater., 196 (2011) 1–15.
  50. E.R. Cooper, T.C. Siewicki, K. Phillips, Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment, Sci. Total Environ., 398 (2008) 26–33.
  51. M.D. Hernando, M. Mezcua, A.R. Fernández-Alba, D. Barceló, Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments, Talanta, 69 (2006) 334–342.
  52. X. Liang, B. Chen, X. Nie, Z. Shi, X. Huang, X. Li, The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China, Chemosphere, 92 (2013) 1410–1416.
  53. M. Seifrtová, L. Nováková, C. Lino, A. Pena, P. Solich, An overview of analytical methodologies for the determination of antibiotics in environmental waters, Anal. Chim. Acta., 649 (2009) 158–179.
  54. E. Zuccato, D. Calamari, M. Natangelo, R. Fanelli, Presence of therapeutic drugs in the environment, Lancet, 355 (2000) 1789–1790.
  55. C. Rodríguez-Navas, E. Björklund, S.A. Bak, M. Hansen, K.A. Krogh, F. Maya, R. Forteza, V. Cerdá, Pollution pathways of pharmaceutical residues in the aquatic environment on the Island of Mallorca, Spain, Arch. Environ. Contam. Toxicol., 65 (2013) 56–66.
  56. S.P. Singh, A. Azua, A. Chaudhary, S. Khan, K.L. Willet, P.R. Gardinali, Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments, Ecotoxicology, 19 (2010) 338–350.
  57. G.M.A. Lucero, G.M. Marcela, G.M. Sandra, G.O.L. Manuel, R.E. Celene, Naproxen-enriched artificial sediment induces oxidative stress and genotoxicity in Hyalella Azteca, Water Air Soil Pollut., 226 (2015) 1–10.
  58. D. Camacho-Muñoz, J. Martin, J.L. Santos, I. Aparicio, E. Alonso, Distribution and risk assessment of pharmaceutical compounds in river sediments from Doñana Park (Spain), Water Air Soil Pollut., 224 (2013) 1–15.
  59. M. Farré, M. Gros, B. Hernández, M. Petrovic, P. Hancock, D. Barceló, Analysis of biologically active compounds in water by ultra-performance liquid chromatography quadrupole timeof- flight mass spectrometry, Rapid Commun. Mass Spectrom., 22 (2008) 41–51.
  60. M.S. Fram, K. Belitz, Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California, Sci. Total Environ., 409 (2011) 3409–3417.
  61. J.-W. Kim, H.-S. Jang, J.-G. Kim, H. Ishibashi, M. Hirano, K. Nasu, N. Ichikawa, Y. Takao, R. Shinohara, K. Arizono, Occurrence of pharmaceutical and personal care products (PPCPs) in Surface water from Mankyung River, South Korea, J. Health Sci., 55 (2009) 249–258.
  62. T.V. Madureira, M.J. Rocha, Q.B. Cass, M.E. Tiritan, Development and optimization of a HPLC–DAD method for the determination of diverse pharmaceuticals in estuarine surface waters, J. Chromatogr. Sci., 48 (2010) 176–182.
  63. I.T. Carvalho, L. Santos, Antibiotics in the aquatic environments: a review of the European scenario, Environ. Int., 94 (2016) 736–757.
  64. L. Vergeynst, A. Haeck, P. Wispelaere, H. Langenhove, K. Demeestere, Multiresidue analysis of pharmaceuticals in wastewater by liquid chromatography-magnetic sector mass spectrometry: method quality assessment and application in a Belgian case study, Chemosphere, 119 (2015) S2–S8.
  65. I. Senta, S. Terzic, M. Ahel, Occurrence and fate of dissolved and particulate antimicrobials in municipal wastewater treatment, Water Res., 47 (2013) 705–714.
  66. O. Golovko, V. Kumar, G. Fedorova, T. Randak, R. Grabic, Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant, Chemosphere, 111 (2014) 418–426.
  67. T. Tylová, M. Flieger, J. Olšovská, Determination in antibiotics in influents and effluents of wastewater-treatment-plants in the Czech Republic-development and application of the SPE and a UHPLC-ToFMS method, Anal. Methods, 5 (2013) 2110–2118.
  68. L. Pasquini, J.F. Munoz, M.N. Pons, J. Yvon, X. Dauchy, X. France, N.D. Le, C. France-Lanord, T. Görner, Occurrence of eight household micropollutants in urban wastewater and their fate in a wastewater treatment plant, Sci. Total Environ., 481 (2014) 459–468.
  69. M. Baumann, K. Weiss, D. Maletzki, W. Schussler, D. Schudoma, W. Kopf, U. Kuhnen, Aquatic toxicity of the macrolide antibiotic clarithromycin and its metabolites, Chemosphere, 120 (2015) 192–198.
  70. D. Maier, L. Blaha, J.P. Giesy, A. Henneberg, H.R. Köhler, B. Kuch, R. Osterauer, K. Peschke, D. Richter, M. Scheurer, R. Triebskorn, Biological plausibility as a tool to associate analytical data for micropollutants and effect potential in wastewater, surface water, and sediments with effects in fishes, Water Res., 72 (2015) 127–144.
  71. J. Rossmann, S. Schubert, R. Gurke, R. Oertel, W. Kirch, Simultaneous determination of most prescribed antibiotics in multiple urban wastewater by SPE-LS-MS/MS, J. Chromatogr. B, 969 (2014) 162–170.
  72. M. Papageorigiou, C. Kosma, D. Lambropoulou, Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece, Sci. Total Environ., 543 (2016) 547–569.
  73. C.I. Kosma, D.A. Lambropoulou, T.A. Albanis, Investigation of PPCPs in wastewater treatment plants in Greece: occurrence, removal and environmental risk assessment, Sci. Total Environ., 466–467 (2014) 421–438.
  74. G. Mceneff, L. Barron, B. Kelleher, B. Paull, B. Quinn, A yearlong study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves, Sci. Total Environ., 476–477 (2014) 317–326.
  75. R. Celano, A.L. Piccinelli, L. Campone, L. Rastrelli, Ultrapreconcentration and determination of selected pharmaceutical and personal care products in different water matrices by solid-phase extraction combined with dispersive liquidliquid microextraction prior to ultra-high-pressure liquid chromatography, J. Chromatogr. A, 1355 (2014) 26–35.
  76. P. Verlicchi, M. Al Aukidy, A. Jelic, M. Petrovic, D. Barcelo, Comparison of measured and predicted concentrations of selected pharmaceuticals in wastewater and surface water: a case study of a catchment area in the Po Valley (Italy), Sci. Total Environ., 470–471 (2014) 844–854.
  77. M. Al Aukidy, P. Verlicchi, A. Jelic, M. Petrovic, D. Barceló, Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy, Sci. Total Environ., 438 (2012) 15–25.
  78. P. Verlicchi, M. Al Aukidy, A. Galletti, M. Petrovic, D. Barceló, Hospital effluent: Investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment, Sci. Total Environ., 430 (2012) 109–118.
  79. A.M. Pereira, L.J. Silva, L.M. Meisel, C.M. Lino, A. Pena, Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment, Environ Res., 136 (2015) 108–119.
  80. L.H.M.L.M. Santos, M. Gros, S. Rodriquea-Mozaz, C. Delerue- Matos, A. Pena, D. Barceló, M.C. Montenegro, Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals, Sci. Total Environ., 461–462 (2013) 302–316.
  81. O. Opris, M.L. Soran, V. Coman, F. Copaciu, D. Ristoiu, Determination of some frequently used antibiotics in waste waters using solid-phase extraction followed by highperformance liquid chromatography with diode array and mass spectrometry detection, Cent. Eur. J. Chem., 11 (2013) 1343–1351.
  82. L. Birošová, T. Mackulak, I. Bodík, J. Ryba, J. Škubák, R. Grabic, Pilot study of seasonal occurrence and distribution of antibiotics and drug-resistant bacteria in wastewater treatment plants in Slovakia, Sci. Total Environ., 490 (2014) 440–444.
  83. L. Ferrando-Climent, S. Rodriguez-Mozaz, D. Barceló, Incidence of anticancer drugs in an aquatic urban system: from hospital effluents through urban wastewater to natural environment, Environ. Pollut., 193 (2014) 216–223.
  84. N. Collado, S. Rodriguez-Mozaz, M. Gros, A. Rubirola, D. Barceló, J. Comas, I. Rodriguez-Roda, G. Buttiglieri, Pharmaceuticals occurrence in a WWTP with significant industrial contribution and its input into the river system, Environ. Pollut., 185 (2014) 202–212.
  85. M. Gros, S. Rodriguez-Mozaz, D. Barceló, Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-highperformance liquid chromatography coupled to quadrupolelinear ion trap tandem, J. Chromatogr. A, 1248 (2012) 104–121.
  86. E. Gracia-Lor, J.V. Sancho, R. Serrano, F. Hernández, Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia, Chemosphere, 87 (2012) 453–462.
  87. R. Grabic, J. Fick, R.H. Lindberg, G. Fedorova, M. Tysklind, Multiresidue method for trace level determination of pharmaceuticals in environmental samples using liquid chromatography coupled to triple quadrupole mass spectrometry, Talanta, 100 (2012) 183–195.
  88. S. Coutu, V. Wyrsch, H.K. Wynn, L. Rossi, D.A. Barry, Temporal dynamics of antibiotics in wastewater treatment plant influent, Sci. Total Environ., 458–460 (2013) 20–26.
  89. K.S. Foppe, D.R. Hammond-Weinberger, B. Subedi, Estimation of the consumption of illicit drugs during special events in two communities in Western Kentucky, USA using sewage epidemiology, Sci. Total Environ., 633 (2018) 249–256.
  90. M. Tahergorabi, A. Esrafili, M. Kermani, M. Gholami, M. Farzadkia, Degradation of four antibiotics from aqueous solution by ozonation: intermediates identification and reaction pathways, Desal. Wat. Treat., 139 (2019) 277–287.
  91. N. Ahmadpour, M.H. Sayadi, A. Verma, B. Mansouri, Ultrasonic degradation of ibuprofen from the aqueous solution in the presenceof titanium dioxide nanoparticles/hydrogen peroxide, Desal. Wat. Treat., 145 (2019) 291–299.
  92. R. Nowak, E. Wiśniowska, M. Włodarczyk-Makuła, Effectiveness of degradation and removal of non-steroidal pharmaceuticals which are the most frequently identified in surface water, Desal. Wat. Treat., 134 (2018) 211–223.
  93. A.J. Skees, K.S. Foppe, B. Loganathan, B. Subedi, Contamination profiles, mass loadings, and sewage epidemiology of neuropsychiatric and illicit drugs in wastewater and river waters from a community in the Midwestern United States, Sci. Total Environ., 631–632 (2018) 1457–1464.