References

  1. D.W. Graham, C.W. Knapp, B.T. Christensen, S. McCluskey, J. Dolfing, Appearance of β-lactam-resistance genes in agricultural soils and clinical isolates over the 20th century, Sci. Rep., 6 (2016) 1–8.
  2. P. Dadgostar, Antimicrobial resistance: implications and costs, Infect. Drug Resist., 12 (2019) 3903–3910.
  3. E.R. Choffnes, D.A. Relman, A. Mack, Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies, Workshop Summary, National Academic Press, Washington, D.C., 2010.
  4. T. Jäger, N. Hembach, C. Elpers, A. Wieland, J. Alexander, C. Hiller, G. Krauter, T. Schwartz, Reduction of antibiotic resistant bacteria during conventional and advanced wastewater treatment, and the disseminated loads released to the environment, Front. Microbiol., 9 (2018) 2599, doi: 10.3389/fmicb.2018.02599.
  5. L. Birošová, T. Mackulak, I. Bodík, J. Ryba, J. Škubák, R. Grabic, Pilot study of seasonal occurrence and distribution of antibiotics and drug resistant bacteria in wastewater treatment plants in Slovakia, Sci. Total Environ., 490 (2014) 440–444.
  6. T. Jäger, J. Alexander, S. Kirchen, A. Dötsch, A. Wieland, C. Hiller, T. Schwartz, Live-dead discrimination analysis, qPCR assessment for opportunistic pathogens, and population analysis at ozone wastewater treatment plants, Environ. Pollut., 232 (2018) 571–579.
  7. M.I. Uyaguari-Díaz, M.A. Croxen, Z. Luo, K.I. Cronin, M. Chan, W.N. Baticados, M.J. Nesbitt, S. Li, K.M. Miller, D. Dooley, W. Hsiao, J.L. Isaac-Renton, P. Tang, N. Prystajecky, Human activity determines the presence of integron-associated and antibiotic resistance genes in Southwestern British Columbia, Front. Microbiol., 9 (2018) 852, doi: 10.3389/fmicb.2018.00852.
  8. O. World Health, WHO Report on Surveillance of Antibiotic Consumption: 2016–2018 Early Implementation, World Health Organization, Geneva, 2018.
  9. E. Golfeshan, S. Heidari, M. Abbasi, M. Vahedian, H. Dehghani Khorramabadi, B. Abdi, M. Rasouli, Z. Mahdaviasl, Investigation on the states of antibiotics prescription in hospitals in Qom, Iran, during 2019, Qom Univ. Med. Sci. J., 14 (2020) 12–21.
  10. A. Tafti, H. Zandi, M. Vakli, S.M. Mousavi, M. Zarei, Frequency of β-lactamase and metallo-β-lactamase in Pseudomonas aeruginosa strains isolated from burn wounds in Yazd burn hospital during 2011–2012, Feyz, 18 (2014) 167–174.
  11. E. Farrokhnazar, P. Khaki, S. Moradi Bidhendi, Investigation of AmpC & esbl genes in Escherichia coli isolated from human and poultry, World J. Microbiol., 7 (2014) 138–147.
  12. C. Juan, G. Torrens, M. González-Nicolau, A. Oliver, Diversity and regulation of intrinsic β-lactamases from nonfermenting and other gram-negative opportunistic pathogens, FEMS Microbiol. Rev., 41 (2017) 781–815.
  13. T.O. Abike, O.A. Olufunke, O.O. Temitope, Prevalence of extended spectrum-lactamases in multidrug resistant strains of gram-negative bacteria, Afr. J. Microbiol. Res., 12 (2018) 147–151.
  14. M.I. Bahl, S.J. Sørensen, L.H. Hansen, T.R. Licht, Effect of tetracycline on transfer and establishment of the tetracyclineinducible conjugative transposon Tn916 in the guts of gnotobiotic rats, Appl. Environ. Microbiol., 70 (2004) 758–764.
  15. L. Rahimzadeh Torabi, M. Doudi, Z. Golshani, The frequency of blaIMP and blaVIM carbapenemase genes in clinical isolates of Pseudomonas aeruginosa in Isfahan medical centers, Med. J. Mashhad Univ. Med. Sci., 59 (2016) 139–147.
  16. N. Yousefi Nojookambari, S. Yazdansetad, A. Ardebili, M. Saki, E. Najjari, Detection of intercellular adhesion (ICA) genes involved in biofilm and slime formation in clinical isolates of Staphylococcus aureus harboring mecA gene, J. Babol Univ. Med. Sci., 20 (2018) 27–35.
  17. M. Moghadasi, D. Kalantar-Neyestanaki, M. Karami-Zarandi, H.A. Rahdar, S. Jasemi, M.M. Feizabadi, Investigation of antimicrobial susceptibility patterns and frequency of bla OXA genes in carbapenem resistant Acinetobacter baumannii strains, Sci. J. Kurdistan Univ. Med. Sci., 23 (2018) 108–119.
  18. A. Vafadar-Nejad, A. Rashki, M. Najimi, Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus isolates collected from clinical samples in the Sistan Region, Iran the Sistan region, J. Clin. Med. Res., 2 (2017) 117–123.
  19. D. Subedi, A.K. Vijay, G.S. Kohli, S.A. Rice, M. Willcox, Nucleotide sequence analysis of NPS-1 β-lactamase and a novel integron (In 1427)-carrying transposon in an MDR Pseudomonas aeruginosa keratitis strain, J. Antimicrob. Chemother., 73 (2018) 1724–1726.
  20. M. Shahmoradi, M. Gholami, M. Mahaee, E. Abouee Mehrizi, R. Ghorbanpoor, Investigation into organic matter and nutrient removal in an activated sludge wastewater treatment system: case study of Bojnurd, J. North Khorasan Univ. Med. Sci., 5 (2014) 927–933.
  21. R.D. Reihani, M. Roshani, M. Farshchian, Determination of antibiotic resistance spectrum in Enterobacteriaceae and Staphylococcus bacteria isolated from hospital wastewaters in Tabriz, Med. J. Tabriz Univ. Med. Sci., 40 (2018) 24–30.
  22. M. Piotrowska, S. Kowalska, M. Popowska, Diversity of β-lactam-resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant, Ann. Microbiol., 69(2019) 591–601.
  23. G.S. Zagui, L.N. de Andrade, N.C. Moreira, T.V. Silva, G.P. Machado, A.L. da Costa Darini, S.I. Segura-Muñoz, Gram-negative bacteria carrying β-lactamase encoding genes in hospital and urban wastewater in Brazil, Environ. Monit. Assess., 192 (2020) 1–11.
  24. M. Ghane, R. Khanpour Zarenji, Detection of antibiotic resistant gram negative bacteria and plasmid profiling of multi-drug resistant isolates in hospital effluents, Med. Sci. J. Islamic Azad Univ., 24 (2015) 235–241.
  25. F. Yang, D. Mao, H. Zhou, Y. Luo, Prevalence and fate of carbapenemase genes in a wastewater treatment plant in northern China, PLoS One, 11 (2016) e0156383, doi: 10.1371/journal.pone.0156383.
  26. F.A. Khan, B. Söderquist, J. Jass, Prevalence and diversity of antibiotic resistance genes in Swedish aquatic environments impacted by household and hospital wastewater, Front. Microbiol., 10 (2019) 688, doi: 10.3389/fmicb.2019.00688.
  27. F. Ju, K. Beck, X. Yin, A. Maccagnan, C.S. McArdell, H.P. Singer, D.R. Johnson, T. Zhang, H. Bürgmann, Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes, The ISME J., 13 (2019) 346–360.
  28. H. Volkmann, T. Schwartz, S. Kirchen, C. Stofer, U. Obst, Evaluation of inhibition and cross-reaction effects on realtime PCR applied to the total DNA of wastewater samples for the quantification of bacterial antibiotic resistance genes and taxon-specific targets, Mol. Cell. Probes, 21 (2007) 125–133.
  29. magen-tec.com, Wizard® Genomic DNA Purification Kit, 2015. Available at https://worldwide.promega.com/-/media/files/ resources/protocols/technical-manuals/0/wizard-genomic-dnapurification- kit-protocol.pdf
  30. M. Asadi-Ghalhari, R. Aali, M. Aghanejad, R.F. Fard, H. Izanloo, A. Shahryari, H. Mirhossaini, M.M. Rabori, R. Ghanbari, Effects of different wastewater treatment processes on occurrence and prevalence of antibiotic resistant bacteria and their resistance genes, J. Environ. Treat., 8 (2020) 744–749.
  31. H. Zipper, C. Buta, K. Lämmle, H. Brunner, J. Bernhagen, F. Vitzthum, Mechanisms underlying the impact of humic acids on DNA quantification by SYBR Green I and consequences for the analysis of soils and aquatic sediments, Nucleic Acids Res., 31 (2003) e39, doi: 10.1093/nar/gng039.
  32. D.H. Mathews, J. Sabina, M. Zuker, D.H. Turner, Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure, J. Mol. Biol., 288 (1999) 911–940.
  33. R. Ghanbari, A. Shahryari, E. Asgari, S. Hosseinpoor, J. Yeganeh, Diversity of genes coding of antibiotic resistance in municipal wastewaters, Rahavard Salamat J., 2 (2016) 1–14 (In Persian).
  34. R. Aali, S. Baragh, E. Asgari, R. Fouladi Fard, H. Izanloo, S. Hosseinpoor, J. Bagheri Hamzyan Olia, R. Naseri, M. Mehdipour Rabori, Tracking of chloramphenicol, erythromycin, and sulfamethoxazole antibiotic-resistant bacteria from untreated wastewater effluents to receiving river, Environ. Eng. Manage. J., 6 (2019) 89–96.
  35. K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar, MEGA6: molecular evolutionary genetics analysis version 6.0, Mol. Biol. Evol., 30 (2013) 2725–2729.
  36. J. Felsenstein, Confidence limits on phylogenies: an approach using the bootstrap, Evolution, 39 (1985) 783–791.
  37. National Library of Medicine (US), National Center for Biotechnology Information, 1988, (Cited 2017 Apr. 06). Available at https://www.ncbi.nlm.nih.gov/
  38. H. Heuer, A. Focks, M. Lamshöft, K. Smalla, M. Matthies, M. Spiteller, Fate of sulfadiazine administered to pigs and its quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil, Soil Biol. Biochem., 40 (2008) 1892–1900.
  39. L.R. Merz, D.K. Warren, M.H. Kollef, V.J. Fraser, Effects of an antibiotic cycling program on antibiotic prescribing practices in an intensive care unit, Antimicrob. Agents Chemother., 48 (2004) 2861–2865.
  40. E. Udo, H. Love, W. Grubb, Intra- and inter-species mobilisation of non-conjugative plasmids in staphylococci, J. Med. Microbiol., 37 (1992) 180–186.
  41. N. Franceschini, M. Perilli, B. Segatore, D. Setacci, G. Amicosante, A. Mazzariol, G. Cornaglia, Ceftazidime and aztreonam resistance in Providencia stuartii: characterization of a natural TEM-derived extended spectrum
    β-lactamase, TEM-60, Antimicrob. Agents Chemother., 42 (1998) 1459–1462.
  42. K. Fattahi, A. Rostamzad, Distribution of blaCTX-M, blaTEM genes among ESBL producing Proteus species isolated from urinary tract infections (UTI) in Ilam, J. Res. Med. Sci., 39 (2015) 41–47.
  43. O. Thakali, J.P. Brooks, S. Shahin, S.P. Sherchan, E. Haramoto, Removal of antibiotic resistance genes at two conventional wastewater treatment plants of Louisiana, USA, Water, 12 (2020) 1729, doi: 10.3390/w12061729.
  44. L. Poirel, D. Girlich, T. Naas, P. Nordmann, OXA-28, an extended-spectrum variant of OXA-10 β-lactamase from Pseudomonas aeruginosa and its plasmid-and integron-located gene, Antimicrob. Agents Chemother., 45 (2001) 447–453.
  45. B. Sarma, C. Acharya, S. Joshi, Pseudomonads: a versatile bacterial group exhibiting dual resistance to metals and antibiotics, Afr. J. Microbiol. Res., 4 (2010) 2828–2835.
  46. I. Zerva, I. Alexandropoulou, M. Panopoulou, P. Melidis, S. Ntougias, Antibiotic resistance gene profiles at various treatment stages of a full-scale municipal sewage plant, Desal. Water Treat., 167 (2019) 412–421.
  47. Y. Zhang, Y. Zhuang, J. Geng, H. Ren, Y. Zhang, L. Ding, K. Xu, Inactivation of antibiotic resistance genes in municipal wastewater effluent by chlorination and sequential UV/chlorination disinfection, Sci. Total Environ., 512 (2015) 125–132.
  48. X. Lin, J. Ruan, L. Huang, J. Zhao, Y. Xu, Comparison of the elimination effectiveness of tetracycline and AmpC β-lactamase resistance genes in a municipal wastewater treatment plant using four parallel processes, Ecotoxicol. Environ. Saf., 30 (2021) 1586–1597.
  49. W. Zieliński, E. Korzeniewska, M. Harnisz, J. Hubeny, M. Buta, D. Rolbiecki, The prevalence of drug-resistant and virulent Staphylococcus spp. in a municipal wastewater treatment plant and their spread in the environment, Environ. Int., 143 (2020) 105914, doi: 10.1016/j.envint.2020.105914.
  50. Q. Wen, L. Yang, R. Duan, Z. Chen, Monitoring and evaluation of antibiotic resistance genes in four municipal wastewater treatment plants in Harbin, Northeast China, Environ. Pollut., 212 (2016) 34–40.
  51. I. Zerva, N. Remmas, I. Kagalou, P. Melidis, M. Ariantsi, G. Sylaios, S. Ntougias, Effect of chlorination on microbiological quality of effluent of a full-scale wastewater treatment plant, Life (Basel), 11 (2021) 68, doi: 10.3390/life11010068.
  52. A. Kumar, D. Pal, Antibiotic resistance and wastewater: correlation, impact and critical human health challenges, J. Environ. Chem., 6 (2018) 52–58.